|
学位
|
|
刊行論文
|
1.
|
原著
|
Production of hybrid macrolide antibiotics by exploiting specific substrate recognition characteristics of multifunctional cytochrome P450 enzyme MycG 2024/09/28
|
|
2.
|
原著
|
異なる方法で調製したブロー氏液及びネオ・ブロー氏液の安定性と抗菌活性の評価 2024/09/01
|
|
3.
|
原著
|
Actinoplanes kirromycinicus sp. nov., isolated from soil. 2024/06/26
|
|
4.
|
原著
|
Isolation of Hydrazide-alkenes with Different Amino Acid Origins from an Azoxy-alkene-Producing Mutant of Streptomyces rochei 7434AN4 2023/09/22
|
|
5.
|
原著
|
Methyl-β-D-glucopyranoside from Scabiosa comosa as a Quorum Sensing Inhibitor. 2022/11/22
|
|
6.
|
原著
|
Isolation, Biosynthetic Investigation, and Biological Evaluation of Maniwamycin G, an Azoxyalkene Compound from Streptomyces sp. TOHO-M025. 2022/07/11
|
|
7.
|
その他
|
Bioactive compounds and molecular diversity of endophytic actinobacteria isolated from desert plants. 2021/11/17
|
|
8.
|
原著
|
Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450 2021/09/20
|
|
9.
|
原著
|
A Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. 2021/08/20
|
|
10.
|
原著
|
Actinocatenispora comari sp. nov., an endophytic actinomycete isolated from aerial parts of Comarum salesowianum 2021/07/09
|
|
11.
|
総説
|
An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains 2021/03/12
|
|
12.
|
原著
|
Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics. 2020/10/21
|
|
13.
|
原著
|
Artificial control of the multistep oxidation reactions catalyzed by the cytochrome P450 enzyme RosC. 2020/02/26
|
|
14.
|
原著
|
Quorum sensing inhibitors against Chromobacterium violaceum CV026 derived from an actinomycete metabolite library. 2020/01
|
|
15.
|
原著
|
Monitoring the colonization and infection of legume nodules by Micromonospora in co-inoculation experiments with rhizobia. 2017/09
|
|
16.
|
原著
|
Cytochrome P450 enzyme RosC catalyzes a multistep oxidation reaction to form the non-active compound 20-carboxyrosamicin 2017/07
|
|
17.
|
原著
|
Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025 2016/05
|
|
18.
|
原著
|
Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases 2015/05
|
|
19.
|
その他
|
放線菌のセシウム蓄積に関する研究 2014/12
|
|
20.
|
原著
|
A new mycinosyl rosamicin derivative produced by an engineered Micromonospora rosaria mutant with a cytochrome P450 gene disruption introducing the D-mycinose biosynthetic gene. 2014/09
|
|
21.
|
原著
|
New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners. 2014/02
|
|
22.
|
原著
|
Isolation and structural elucidation of novel cholestane glycosides and spirostane saponins from Polygonatum odoratum 2014/01
|
|
23.
|
原著
|
Piericidins, novel quorum-sensing inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348. 2013/12
|
|
24.
|
原著
|
Surveillance of Fluoroquinolone-Resistant Clinical Isolates of Pseudomonas aeruginosa. 2013/06
|
|
25.
|
原著
|
Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria 2013/03
|
|
26.
|
原著
|
Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041. 2012/11
|
|
27.
|
原著
|
Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions 2012/11
|
|
28.
|
原著
|
Function of the cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin. 2012/07
|
|
29.
|
原著
|
A new structural form in the SAM/metal-dependent O-methyltransferase family: MycE from the mycinamycin biosynthetic pathway. 2011/10
|
|
30.
|
原著
|
Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. 2011/08
|
|
31.
|
原著
|
Characteristics of cesium accumulation in the filamentous soil bacterium Streptomyces sp. K202. 2011/02
|
|
32.
|
原著
|
Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin—a new rosamicin analogue derived from engineered Micromonospora rosaria. 2010/06
|
|
33.
|
原著
|
Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with disruption cassette containing bacteriophage øC31 attB attachment site 2010/03
|
|
34.
|
原著
|
Identification of the Tirandamycin Biosynthetic Gene Cluster from Streptomyces sp. 307-9. 2010/03
|
|
35.
|
原著
|
Production of rosamicin derivatives in Micromonospora rosaria by introduction of D-mycinose biosynthetic gene with phiC31-derived integration vector pSET152. 2009/08
|
|
36.
|
原著
|
Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics. 2009/05
|
|
37.
|
原著
|
Accumulation and localization of cesium in edible mushroom (Pleurotus ostreatus) mycelia. 2008
|
|
38.
|
原著
|
Detection and identification of species with bacterial cells using a plastic DNA array. 2008
|
|
39.
|
原著
|
Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. 2008
|
|
40.
|
原著
|
Conjugative plasmid transfer in the biofilm formed by Enterococcus faecalis. 2006
|
|
41.
|
原著
|
Degradation of microcystins using immobilized microorganism isolated in a eutrophic lake. 2006
|
|
42.
|
原著
|
The hierarchical system of the 'Alphaproteobacteria': description of Hyphomonadaceae fam. nov., Xanthobacteraceae fam. nov. and Erythrobacteraceae fam. nov. 2005
|
|
43.
|
原著
|
Hybrid Biosynthesis by Targeted Inactivation of Polyketide Synthases in the Mycinamicin Producer, Micromonospora griseorubida. 2004
|
|
44.
|
原著
|
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study. 2004
|
|
45.
|
原著
|
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida. 2003
|
|
46.
|
原著
|
Phylogenetic affiliation of the Pseudomonads based on 16S rRNA sequence. 2000
|
|
47.
|
原著
|
16S rRNA gene sequence analysis of Streptomyces lavendulae and Streptomyces virginiae strains. 1997
|
|
48.
|
原著
|
The phylogeny of the genera Chryseomonas, Flavimonas, and Pseudomonas supports synonymy of these tree genera. 1997
|
|
49.
|
原著
|
Monamidocin, a novel fibrinogen receptor antagonist. I. Production, isolation, characterization and structural elucidation. 1995
|
|
50.
|
原著
|
Application of the random amplified polymorphic DNA using the polymerase chain reaction for efficient elimination of duplicate strains in microbial screening. II. Actinomycetes. 1994
|
|
51.
|
原著
|
Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. I. Taxonomy, yield improvement, and fermentation. 1993
|
|
52.
|
原著
|
Isolation of bacterial strains, which hydrolyze glycyrrhizin and produce glycyrrhezic acid, from soil. 1990
|
|
10件表示
|
|
全件表示(52件)
|
|
|
著書
|
| プロフィール |
|
学歴
| 1. |
1988/04～1990/03
|
東邦大学 薬学研究科 修士課程修了
|
| 2. |
1999/12
(学位取得)
|
東京大学 博士（農学）
|
|
|
職歴
|
1.
|
1990/04～1999/03
|
日本ロシュ㈱研究所 研究員
|
|
2.
|
1999/04～2004/02
|
東邦大学 薬学部 薬学科 助手
|
|
3.
|
2004/03～2010/05
|
東邦大学 薬学部 薬学科 講師
|
|
4.
|
2010/06～2015/03
|
東邦大学 薬学部 薬学科 准教授
|
|
5.
|
2013/04～
|
東邦大学 理学部 兼担講師
|
|
6.
|
2015/04～
|
東邦大学 薬学部 薬学科 教授
|
|
7.
|
2017/04～
|
東邦大学 健康科学部 兼担講師
|
|
|
所属学会
|
1.
|
|
日本放線菌学会
|
|
2.
|
1999/04～2018/03
|
∟ 学術企画委員
|
|
3.
|
2014/04～2018/03
|
∟ 理事
|
|
4.
|
2018/04～
|
∟ 学術企画委員会 アドバイザー
|
|
5.
|
2024/04～
|
∟ 監事
|
|
6.
|
|
日本薬学会
|
|
7.
|
2023/02～
|
∟ 代議員
|
|
|
受賞学術賞
| 1. |
2005/01 |
東邦大学 東邦大学 額田奨学金 (放線菌の二次代謝に関する研究)
|
|
|
取得特許
|
1.
|
2010/03/11
|
Mycinose生合成遺伝子を導入した微生物（JP 2010051243）
|
|
|
研究課題・受託研究・科研費
|
