教員情報 - 神林　隆一

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刊行論文

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研究課題・受託研究・科研費

（最終更新日：2025-06-26 12:51:07）

  カンバヤシ　リュウイチ   Kambayashi Ryuichi
  神林　隆一
   所属   東邦大学医学部医学科

職種助教

学位

博士(薬学)

刊行論文

1.	原著	Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs. 2022/08/12
2.	原著	Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts. 2022/02
3.	原著	Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: reverse translational study. 2022/01
4.	原著	Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model. 2022/01
5.	原著	Effects of cardiac massage and β-blocker pretreatment on the success rate of cardiopulmonary resuscitation assessed by the canine ischemia/reperfusion-induced ventricular fibrillation model. 2021/10/01
6.	原著	Measurement of early and late repolarization periods in addition to QT interval to help predict the torsadogenic risk of donepezil based on reverse translational animal research on its proarrhythmic potential. 2021/09/10
7.	原著	Translational studies on anti-atrial fibrillatory action of oseltamivir by its in vivo and in vitro electropharmacological analyses. 2021/04/29
8.	原著	Cardiohemodynamic and arrhythmogenic effects of the anti-atrial fibrillatory compound vanoxerine in halothane-anesthetized dogs. 2021/04
9.	原著	Effects of mechanical ventilation with expiratory negative airway pressure on porcine pulmonary and systemic circulation: mechano-physiology and potential application. 2021/04
10.	原著	Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. 2021/03
11.	原著	In vivo characterization of anti-atrial fibrillatory potential and pharmacological safety profile of I_Na,Lplus I_Kr inhibitor ranolazine using the halothane-anesthetized dogs. 2021/03
12.	原著	Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs. 2021/03
13.	原著	An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation. 2021/01
14.	原著	In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs. 2021/01
15.	原著	In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state. 2021/01
16.	原著	Torsadogenic action of cisapride, dl-sotalol, bepridil, and verapamil analyzed by the chronic atrioventricular block cynomolgus monkeys: Comparison with that reported in the CiPA in silico mechanistic model. 2021/01
17.	原著	Optimizing the direction and order of the motion unveiled the ability of conventional monolayers of human induced pluripotent stem cell-derived cardiomyocytes to show frequency-dependent enhancement of contraction and relaxation motion. 2020/08/19
18.	原著	In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys. 2020/05/13
19.	原著	Risperidone alone did not induce torsade de pointes: experimental evidence from the chronic atrioventricular block model dogs. 2020/05/13
20.	原著	Analysis of electropharmacological effects of AVE0118 on the atria of chronic atrioventricular block dogs: characterization of anti-atrial fibrillatory action by atrial repolarization-delaying agent. 2020/04/20
21.	原著	Characterization of microminipig as a laboratory animal for pharmacological study by analyzing bepridil-induced cardiovascular responses. 2020/04
22.	原著	Electropharmacological characterization of aciclovir in the halothane-anesthetized dogs: a proposal of evaluation method for cardiovascular safety pharmacology of anti-virus drugs. 2020/03/17
23.	原著	Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium. 2020/03
24.	原著	Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes. 2020/03
25.	原著	Dasatinib can impair left ventricular mechanical function but may lack proarrhythmic effect: a proposal of non-clinical guidance for predicting clinical cardiovascular adverse events of tyrosine kinase inhibitors. 2020/02
26.	原著	How the deuteration of dronedarone can modify its cardiovascular profile: in vivo characterization of electropharmacological effects of poyendarone, a deuterated analogue of dronedarone. 2020/01/02
27.	原著	In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval. 2019/10
28.	原著	Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions. 2019/09
29.	原著	Pharmacological β-adrenoceptor blockade can augment torsadogenic action of I_Kr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs. 2019/09
30.	原著	Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings. 2019/07
31.	原著	Electropharmacological effects of intracellular Ca²⁺ handling modulator caldaret on the heart assessed in the halothaneanesthetized dogs. 2019/03
32.	原著	Measurement of J-Tpeakc along with QT-interval prolongation may increase the assay sensitivity and specificity for predicting the onset of drug-induced torsade de pointes: Experimental evidences based on proarrhythmia model animals. 2019/01
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プロフィール

学歴

1.	2024/12/18 (学位取得)	東邦大学博士(薬学)
2.	2025/03/27 (学位取得)	東邦大学博士(医学)

職歴

2018/07～

東邦大学医学部医学科助教

受賞学術賞

1.	2021/03	日本薬理学会第94回日本薬理学会年会年会優秀発表賞
2.	2021/04	日本不整脈心電学会心電学関連春季大会2021 Best Research Award優秀賞
3.	2021/12	日本臨床薬理学会第42回日本臨床薬理学会学術総会優秀演題賞
4.	2025/02	第16回　日本安全性薬理研究会学術年会　優秀研究発表賞

研究課題・受託研究・科研費

1.	2020/04～2023/03	重水素化が抗心房細動薬の循環薬理作用に及ぼす影響の解明と臨床開発への応用
2.	2025/04～2028/03	心不全合併心房細動モデルを活用したSGLT2阻害薬の心房細動治療効果の解明