教員情報 - 野口　修治

学位

博士（薬学、東京大学）

刊行論文

1.	原著	Probing Iodine Atom Interactions in 4-Iodo-L-phenylalanine crystals by X-ray Absorption Near-edge Structure Spectroscopy 2025/07/19
2.	原著	Thermodynamic Perspectives on the Impact of a Second Drug on Amorphous Drug Solubility 2025/06/04
3.	原著	Brominated 3-Acetyl-11-keto-β-boswellic Acid Derivative from Boswellia serrata Extract Characterized by Single-Crystal X-Ray Structure Analysis and Mass Spectroscopy 2025/04/02
4.	原著	Characterization of Bisphosphonate Hydrate Crystals by Phosphorus K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy 2024/04/01
5.	原著	Characterization of Ambroxol and Its Hydrochloride Salt Crystals by Bromine K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and X-Ray Crystal Structure Analysis 2023/09/01
6.	原著	Cocrystal or Salt Crystallization for Active Pharmaceutical Ingredients By Using Deep Eutectic Solvents 2023/08/18
7.	原著	Novel Pharmaceutical Cocrystals and Solvate Crystals of Nobiletin, a Citrus Flavonoid with Potent Pharmacological Activity 2023/08/01
8.	原著	Comparison of the physical properties of disodium etidronate amorphous forms prepared by different manufacturing methods 2023/02/15
9.	原著	Analysis of cimetidine crystal polymorphs by X-ray absorption near-edge spectroscopy. 2022/12/23
10.	原著	Direct detection of the crystal form of active pharmaceutical ingredients in tablets by X-ray absorption fine structure spectroscopy 2022/08/09
11.	原著	C–H···S hydrogen bonds in ampicillin and amoxicillin crystals investigated by sulfur K-edge X-ray absorption near-edge structure spectroscopy and single-crystal X-ray structure analysis 2022/08/07
12.	原著	Bromine K-edge X-ray absorption near-edge structure analysis on hydrobromide-salt crystals and the solid dispersion of active pharmaceutical ingredients 2022/02/01
13.	原著	Salt co-crystallization of loxoprofen sodium with sugar: Reduction of the propensity for hydrate formation by forming a continuous one-dimensional chain structure of sodium and sugar 2021/12/28
14.	原著	Investigation of Physical Properties of Disodium Etidronate Tetrahydrate and Application of Phosphorus K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy 2021/12/17
15.	原著	Reduced deliquescency of isosorbide by cocrystallization and mechanisms for hygroscopicity 2021/09/25
16.	原著	X‑ray Absorption Near-Edge Spectroscopy Analysis of Indomethacin in Crystalline Forms and in Amorphous Solid Dispersions 2021/08/10
17.	原著	Chlorine K‑Edge X‑ray Absorption Near-Edge Structure Discrimination of Crystalline Solvates and Salts in Organic Molecules 2020/07/22
18.	原著	Chlorine K-Edge X-Ray Absorption Near-Edge Structure Analysis of Clarithromycin Hydrochloride Metastable Crystal 2020/05
19.	原著	Correlation between drug dissolution and resistance to water-induced phase separation in solid dispersion formulations revealed by solid-state NMR spectroscopy 2020/03
20.	原著	Structural and biochemical basis of the formation of isoaspartate in the complementarity-determining region of antibody 64M-5 Fab 2019/12
21.	原著	Crystal structures of flavone C-glycosides from oolong tea leaves: chafuroside A dihydrate and chafuroside B monohydrate. 2019/09
22.	原著	Desolvation behavior of indinavir sulfate ethanol and follow-up by terahertz spectroscopy 2019/08
23.	原著	Mechanism of drug release from temperature-sensitive formulations composed of low-melting-point microcrystalline wax. 2019/06
24.	原著	Structures of the antibody 64M-5 Fab and its complex with dT(6–4)T indicate induced-fit and high-affinity mechanisms. 2019/02
25.	原著	Phase transitions of antibiotic clarithromycin forms I, IV and new form VII crystals 2018/08
26.	原著	Mechanism of the formation of hollow spherical granules using a high shear granulator. 2018/05
27.	原著	Stabilization Mechanism of Roxithromycin Tablets Under Gastric pH Conditions. 2018/05
28.	原著	Morphological and physicochemical evaluation of two distinct glibenclamide/hypromellose amorphous nanoparticles prepared by the antisolvent method 2018/04
29.	原著	New scale-down methodology from commercial to lab scale to optimize plant-derived soft gel capsule formulations on a commercial scale. 2018/01
30.	原著	Melt adsorption as a manufacturing method for fine particles of wax matrices without any agglomerates 2017/08
31.	原著	Effect of gel formation on the dissolution behavior of clarithromycin tablets. 2017/04
32.	原著	Mechanisms for Improved Hygroscopicity of L-Arginine Valproate Revealed by X-Ray Single Crystal Structure Analysis 2017/03
33.	原著	Enhancing the solubility and oral bioavailability of poorly water-soluble drugs using monoolein cubosomes 2017/01
34.	原著	Evaluation of the thermosensitive release properties of microspheres containing 2017/01
35.	原著	Application of terahertz attenuated total reflection spectroscopy to detect changes in the physical properties of lactose during the lubrication process required for drug formulation 2016/12
36.	原著	Structure of anti-tumor drug 7-ethyl-10-hydroxycamptothecin monohydrate and its solid state hydrolysis mechanism on heating 2016/12
37.	原著	Saturated fatty acids and fatty acid esters promote the polymorphic transition of clarithromycin metastable form I crystal 2016/10
10件表示
全件表示(37件)

著書

1.	部分執筆	「製剤学・物理薬剤学通論第2版」 2021/09/06
2.	部分執筆	「製剤学・物理薬剤学通論」 2019/09

学会発表

1.	X線吸収微細構造スペクトル測定と計算科学の協働によるインドメタシン共非晶質中の分子間相互作用解析（ポスター掲示，一般） 2025/03/29

学歴

1.		東京大学大学院薬学系研究科博士（薬学）
2.	1989/04～1991/03	東京大学大学院薬学系研究科機能薬学専攻修士課程修了薬学修士
3.	1985/04～1989/03	東京大学薬学部卒業

職歴

1.

2016/04～

東邦大学薬学部薬学科教授

現在の専門分野

薬系分析、物理化学, 医療薬学　（キーワード：物理薬剤学，製剤学）

ホームページ

https://www.lab.toho-u.ac.jp/phar/yakuzai/index.html