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学位
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刊行論文
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1.
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原著
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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity. 2025/12/29
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2.
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原著
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Enzyme engineering of cytochrome P450 RosC provides mechanistic insights into factors controlling iterative oxidation. 2025/12/09
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3.
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原著
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Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa 2025/04/08
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4.
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原著
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Unveiling dynamic hepatocyte plasticity in HepaRG cells with a dual CYP reporter system 2024/11/11
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5.
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原著
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Production of hybrid macrolide antibiotics by exploiting specific substrate recognition characteristics of multifunctional cytochrome P450 enzyme MycG 2024/09/28
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6.
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原著
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異なる方法で調製したブロー氏液及びネオ・ブロー氏液の安定性と抗菌活性の評価 2024/09/01
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7.
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原著
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Actinoplanes kirromycinicus sp. nov., isolated from soil 2024/06/26
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8.
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原著
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Isolation of Hydrazide-alkenes with Different Amino Acid Origins from an Azoxy-alkene-Producing Mutant of Streptomyces rochei 7434AN4 2023/09/22
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9.
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原著
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Methyl-β-D-glucopyranoside from Scabiosa comosa as a Quorum Sensing Inhibitor. 2022/11/22
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10.
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原著
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Isolation, Biosynthetic Investigation, and Biological Evaluation of Maniwamycin G, an Azoxyalkene Compound from Streptomyces sp. TOHO-M025. 2022/07/11
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11.
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その他
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Bioactive compounds and molecular diversity of endophytic actinobacteria isolated from desert plants. 2021/11/17
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12.
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原著
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Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450 2021/09/20
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13.
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原著
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A Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. 2021/08/20
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14.
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原著
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Actinocatenispora comari sp. nov., an endophytic actinomycete isolated from aerial parts of Comarum salesowianum 2021/07/09
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15.
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総説
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An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains 2021/03/12
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16.
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原著
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Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics. 2020/10/21
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17.
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原著
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Artificial control of the multistep oxidation reactions catalyzed by the cytochrome P450 enzyme RosC. 2020/02/26
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18.
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原著
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Quorum sensing inhibitors against Chromobacterium violaceum CV026 derived from an actinomycete metabolite library. 2020/01
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19.
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原著
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Monitoring the colonization and infection of legume nodules by Micromonospora in co-inoculation experiments with rhizobia. 2017/09
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20.
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原著
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Cytochrome P450 enzyme RosC catalyzes a multistep oxidation reaction to form the non-active compound 20-carboxyrosamicin 2017/07
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21.
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原著
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Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025 2016/05
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22.
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原著
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Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases 2015/05
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23.
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その他
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放線菌のセシウム蓄積に関する研究 2014/12
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24.
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原著
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A new mycinosyl rosamicin derivative produced by an engineered Micromonospora rosaria mutant with a cytochrome P450 gene disruption introducing the D-mycinose biosynthetic gene. 2014/09
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25.
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原著
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New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners. 2014/02
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26.
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原著
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Isolation and structural elucidation of novel cholestane glycosides and spirostane saponins from Polygonatum odoratum 2014/01
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27.
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原著
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Piericidins, novel quorum-sensing inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348. 2013/12
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28.
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原著
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Surveillance of Fluoroquinolone-Resistant Clinical Isolates of Pseudomonas aeruginosa. 2013/06
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29.
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原著
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Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria 2013/03
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30.
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原著
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Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041. 2012/11
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31.
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原著
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Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions 2012/11
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32.
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原著
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Function of the cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin. 2012/07
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33.
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原著
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A new structural form in the SAM/metal-dependent O-methyltransferase family: MycE from the mycinamycin biosynthetic pathway. 2011/10
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34.
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原著
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Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. 2011/08
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35.
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原著
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Characteristics of cesium accumulation in the filamentous soil bacterium Streptomyces sp. K202. 2011/02
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36.
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原著
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Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin—a new rosamicin analogue derived from engineered Micromonospora rosaria. 2010/06
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37.
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原著
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Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with disruption cassette containing bacteriophage øC31 attB attachment site 2010/03
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38.
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原著
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Identification of the Tirandamycin Biosynthetic Gene Cluster from Streptomyces sp. 307-9. 2010/03
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39.
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原著
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Production of rosamicin derivatives in Micromonospora rosaria by introduction of D-mycinose biosynthetic gene with phiC31-derived integration vector pSET152. 2009/08
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40.
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原著
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Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics. 2009/05
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41.
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原著
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Accumulation and localization of cesium in edible mushroom (Pleurotus ostreatus) mycelia. 2008
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42.
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原著
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Detection and identification of species with bacterial cells using a plastic DNA array. 2008
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43.
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原著
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Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. 2008
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44.
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原著
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Conjugative plasmid transfer in the biofilm formed by Enterococcus faecalis. 2006
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45.
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原著
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Degradation of microcystins using immobilized microorganism isolated in a eutrophic lake. 2006
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46.
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原著
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The hierarchical system of the 'Alphaproteobacteria': description of Hyphomonadaceae fam. nov., Xanthobacteraceae fam. nov. and Erythrobacteraceae fam. nov. 2005
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47.
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原著
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Hybrid Biosynthesis by Targeted Inactivation of Polyketide Synthases in the Mycinamicin Producer, Micromonospora griseorubida. 2004
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48.
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原著
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The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study. 2004
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49.
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原著
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Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida. 2003
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50.
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原著
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Phylogenetic affiliation of the Pseudomonads based on 16S rRNA sequence. 2000
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51.
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原著
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16S rRNA gene sequence analysis of Streptomyces lavendulae and Streptomyces virginiae strains. 1997
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52.
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原著
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The phylogeny of the genera Chryseomonas, Flavimonas, and Pseudomonas supports synonymy of these tree genera. 1997
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53.
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原著
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Monamidocin, a novel fibrinogen receptor antagonist. I. Production, isolation, characterization and structural elucidation. 1995
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54.
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原著
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Application of the random amplified polymorphic DNA using the polymerase chain reaction for efficient elimination of duplicate strains in microbial screening. II. Actinomycetes. 1994
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55.
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原著
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Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. I. Taxonomy, yield improvement, and fermentation. 1993
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56.
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原著
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Isolation of bacterial strains, which hydrolyze glycyrrhizin and produce glycyrrhezic acid, from soil. 1990
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10件表示
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全件表示(56件)
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著書
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学会発表
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| プロフィール |
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学歴
| 1. |
1988/04～1990/03
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東邦大学 薬学研究科 修士課程修了
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| 2. |
1999/12
(学位取得)
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東京大学 博士（農学）
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職歴
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1.
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1990/04～1999/03
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日本ロシュ㈱研究所 研究員
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2.
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1999/04～2004/02
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東邦大学 薬学部 薬学科 助手
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3.
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2004/03～2010/05
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東邦大学 薬学部 薬学科 講師
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4.
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2010/06～2015/03
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東邦大学 薬学部 薬学科 准教授
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5.
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2013/04～
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東邦大学 理学部 兼担講師
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6.
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2015/04～
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東邦大学 薬学部 薬学科 教授
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7.
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2017/04～
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東邦大学 健康科学部 兼担講師
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所属学会
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1.
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日本放線菌学会
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2.
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1999/04～2018/03
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∟ 学術企画委員
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3.
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2014/04～2018/03
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∟ 理事
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4.
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2018/04～
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∟ 学術企画委員会 アドバイザー
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5.
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2024/04～
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∟ 監事
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6.
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日本薬学会
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7.
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2023/02～2025/01
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∟ 代議員
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8.
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2025/02～
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∟ 関東支部 幹事
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受賞学術賞
| 1. |
2005/01 |
東邦大学 東邦大学 額田奨学金 (放線菌の二次代謝に関する研究)
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取得特許
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1.
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2010/03/11
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Mycinose生合成遺伝子を導入した微生物（JP 2010051243）
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研究課題・受託研究・科研費
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