タカハシ　リョウヤ   Takahashi Ryoya   高橋　良哉    所属   東邦大学  薬学部 薬学科    職種   教授
言語種別	英語
発表タイトル	Reduction of Proteinuria by Dietary Restriction Initiated from Old in Rats.
会議名	2008 Spring Conference of the Korean Society for Gerontology and AVDRC symposium, Yeungnam University. The 8th Korea-Japan Gerontologist Joint Meeting
学会区分	国際学会
招聘	招聘
発表形式	口頭
講演区分	シンポジウム・ワークショップ パネル（その他）
発表者・共同発表者	◎Odera K†, Goto S, Takahashi R†
発表年月日	2008/05/16
開催地 （都市, 国名）	Daegu, Korea
概要	Progressive deterioration of renal structure and function occurs during aging. We previously found that the dietary restriction (DR) initiated even at old age reduced urinary proteins (mostly albumin) within several months. The reduction of proteinuria might be partly due to the activation of uptake and degradation of albumin in the renal proximal tubular cells. In this study, we investigated the effects of age and DR initiated from old age on age-related alteration of endocytic receptors (megalin/cubilin) and the degradation rate of albumin in the kidney of rats. Although there was no difference in the amount of cubilin between the young and old animals, the amount of megalin significantly decreased with age. The late-life DR increased the amount of both receptors in the kidney of rats. On the other hand, no significant effect of age and DR was observed in the degradation rate of FITC-labeled albumin. These observations suggest that the reduction of proteinuria might be due to other mechanisms, such as the improvement in glomerular barrier and/or the activation of transcytosis of albumin by proximal tubular cells rather than the activation of albumin degradation.