スギモト マサズミ   Sugimoto Masazumi
  杉本 雅純
   所属   東邦大学  理学部 生物分子科学科
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka
掲載誌名 正式名:Proceedings of the National Academy of Sciences of the United States of America
略  称:Proc Natl Acad Sci U S A
ISSNコード:00278424/10916490
巻・号・頁 101(29),10661-10666頁
著者・共著者 Fukamachi S, Sugimoto M, Mitani H, Shima A
発行年月 2004/04
概要 Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display widely differing patterns. These contrasting aspects of chromatophores (i.e., the fixed developmental control within species and extreme diversity among species) seem to be a curious and suitable subject for understanding evolution and diversity of organisms. Here we identify a gene responsible for medaka "color interfere" mutants by positional cloning. These mutants do not show any obvious morphological and physiological defects other than defects in chromatophore proliferation and morphogenesis. The mutation has been identified as an 11-base deletion in somatolactin, which causes truncation 91 aa upstream of the C terminus of the protein's 230 aa. Somatolactin transcription changed dramatically during morphological body color adaptation to different backgrounds. This genetic evidence explains somatolactin function. Studying this mutant will provide further insights into the development and regulation of chromatophores and clues for reassessing other functions of somatolactin suggested in other fish.