フジサキ シンゴ   Fujisaki Shingo
  藤崎 真吾
   所属   東邦大学  理学部 生物分子科学科
   職種   教授
論文種別 総説
言語種別 英語
査読の有無 査読あり
招待の有無 招待あり
表題 Undecaprenyl phosphate metabolism in Gram-negative and Gram-positive bacteria
掲載誌名 正式名:Biscience, Biotechnology, and Biochemistry
略  称:Biosci. Biotech. Biochem.
掲載区分国外
出版社 Taylor & Francis
巻・号・頁 82(6),940-946頁
著者・共著者 Kawakami, N.† and Fujisaki, S.*†
発行年月 2018/06
概要 Undecaprenyl phosphate (UP) is essential for the biosynthesis of bacterial extracellular polysaccharides. UP is produced by the dephosphorylation of undecaprenyl diphosphate (UPP) via de novo synthetic and recycling pathways. Gram-positive bacteria contain remarkable amounts of undecaprenol (UOH), which is phosphorylated to UP, although UOH has not been found in Gram-negative bacteria. Here, current knowledge about UPP phosphatase and UOH kinase is reviewed. Dephosphorylation of UPP is catalyzed by a BacA homologue and a type-2 phosphatidic acid phosphatase (PAP2) homologue. The presence of one of these UPP phosphatases is essential for bacterial growth. The catalytic center of both types of enzyme is located outside the cytoplasmic membrane. In Gram-positive bacteria, an enzyme homologous to DgkA, which is the diacylglycerol kinase of Escherichia coli, catalyzes UOH phosphorylation. The possible role of UOH and the significance of systematic construction of Staphylococcus aureus mutants to determine UP metabolism are discussed.