ナカムラ ヒロアキ   Nakamura Hiroaki
  中村 浩章
   所属   東邦大学  医学部 医学科(大橋病院)
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus.
掲載誌名 正式名:Allergology International
略  称:AI
掲載区分国外
出版社 Japanese Society of Allergology.
巻・号・頁 67(2),259-265頁
著者・共著者 Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono,
Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu,
Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
発行年月 2018/04
概要 BACKGROUND:
Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated.

METHODS:
Infants younger than 36 months were enrolled and classified into three groups. Group I included patients hospitalized with RSV-induced bronchitis. These patients were further stratified into two sub-groups according to whether the criteria for the modified Asthma Predictive Index (mAPI) had been met: Group I consisted of mAPI (+) and mAPI (-) patients; Group II included patients with food allergy as a positive control group; and Group III included children with no allergy as a negative control group. Serum periostin and SCCA levels were measured in the groups. This study was registered as a clinical trial (UMIN000012339).

RESULTS:
We enrolled 14 subjects in Group I mAPI (+), 22 in Group I mAPI (-), 18 in Group II, and 18 in Group III. In Group I, the serum periostin and SCCA levels were significantly higher during the acute phase compared with the recovery phase. However, no significant differences were found between Group I mAPI (+) and mAPI (-).

CONCLUSIONS:
The serum periostin and SCCA levels increased during acute RSV bronchitis. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to RSV.