フクモト　アツシ   Fukumoto Atsushi   福本　敦    所属   東邦大学  薬学部 薬学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025
掲載誌名	正式名：The Journal of Antibiotics ISSNコード：00218820
掲載区分	国外
巻・号・頁	69(5),pp.395-399
著者・共著者	Atsushi Fukumoto＊†, Chikana Murakami, Yojiro Anzai† and Fumio Kato†
担当区分	筆頭著者,責任著者
発行年月	2016/05
概要	Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins C–F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The structures of maniwamycins were elucidated by spectroscopic analyses, including NMR. The compounds each have an azoxy moiety. All maniwamycins inhibited violacein synthesis, which is controlled by quorum sensing, in Chromobacterium violaceum CV026.
DOI	10.1038/ja.2015.126