オバラ　ケイスケ   Obara Keisuke   小原　圭将    所属   東邦大学  薬学部 薬学科    職種   准教授
言語種別	英語
発表タイトル	Docosahexaenoic acid (DHA) selectively inhibits prostanoid receptor-mediated contractions in the isolated rat blood vessels.
会議名	The 2nd International Conference on Pharma and Food
主催者	Prof. Shizuo Yamada
学会区分	国際学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Obara K†, Sato K†, Chino D†, Tanaka Y†
発表年月日	2014/11/06
開催地 （都市, 国名）	Nippondaira Hotel, Shizuoka, Japan
学会抄録	Program and Abstracts of The 2nd International Conference on Pharma and Food 107-107
概要	Inhibitory effects of DHA on blood vessel contractions induced by various constrictor stimulants were investigated in the isolated rat thoracic aorta and mesenteric artery. In both blood vessels, DHA exhibited a strong inhibitory effect on the sustained contractions induced by U46619. This inhibitory effect of DHA was not affected by removal of the endothelium or by treatment with either indomethacin or NOS inhibitor. DHA also significantly diminished PGF2alpha-induced contraction but did not show any appreciable inhibitory effects on the contractions to both phenylephrine (PE) and high-KCl. Similarly, eicosapentaenoic acid (EPA) exhibited more potent inhibitory effects against the contractions induced by both U46619 and PGF2alpha than other contractions. In contrast, linoleic acid (LA) did not show significant inhibitory effects against any contractions. The present findings suggest that DHA and EPA elicit more selective inhibition against blood vessel contractions that are mediated through stimulation of prostanoid receptors than those through alpha-adrenoceptor stimulation or membrane depolarization. Selective inhibition by either DHA or EPA of prostanoid receptor-mediated arterial contractions may partly underlie the mechanisms by which these n-3 polyunsaturated fatty acids exert their circulatory-protective effects.