ワカバヤシ　ムネヒロ   Wakabayashi Munehiro   若林　宗弘    所属   東邦大学  医学部 医学科（大森病院）    職種   助教
言語種別	英語
発表タイトル	Prognostic factors in patients with advanced gastric cancer treated with chemotherapy plus immune checkpoint inhibitor
会議名	第23回日本臨床腫瘍学会学術集会（JSMO2026）
学会区分	国内学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Munehiro Wakabayashi†, Yoshinori Kikuchi†, Fumiaki Shiratori†, Kazuhisa Yamaguchi†, Takashi Suzuki†, Yoko Oshima†, Satoshi Yajima†, Yuichiro Otsuka†, Takahisa Matsuda†
発表年月日	2026/03/27
国名	日本
開催地 （都市, 国名）	Yokohama, Japan
開催期間	2026/03/26～2026/03/28
概要	Background: There have been few reports of prognostic factors in patients with advanced gastric cancer (AGC) treated with chemotherapy plus immune check inhibitor (ICI), which is now the standard of care for first-line treatment. Methods: We retrospectively reviewed consecutive patients with untreated AGC who received first-line chemotherapy between November 1, 2021, and March 31, 2025, at our institution. The primary endpoint was to analyze the prognostic factors of AGC patients treated with chemotherapy plus ICI. In this study, overall survival (OS) was calculated using the Kaplan-Meier method, and hazard ratios were calculated using the Cox proportional hazards model. Covariates with a p-value ≤0.10 in the univariate analysis were included in the multivariate analysis, and covariates with a p-value <0.05 in the multivariate analysis were considered to be significant. Results: 64 patients treated with chemotherapy plus ICI were included. Patient characteristics included a median age of 64 years, 34% were male, 63% had ECOG PS 0, 38% had diffuse type, 48% had peritoneal metastasis, 27% had metastatic sites ≥2, 11% had inadequate oral intake, and 5% had massive ascites. The OS was 14.2 months. Based on univariate analysis, inadequate oral intake, albumin <3.5 g/dL, and LDH ≥222 U/L (the upper limit of normal, ULN) were considered significant (p ≤ 0.10). Lastly, inadequate oral intake and LDH ≥ULN were considered prognostic factors in patients with AGC based on multivariate analysis (p < 0.05). Conclusions: Inadequate oral intake and LDH ≥ULN might be prognostic factors in AGC patients treated with chemotherapy plus ICI.