セキ　タカオ   Seki Takao   関　崇生    所属   東邦大学  医学部 医学科    職種   助教
言語種別	英語
発表タイトル	Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis
会議名	第52回免疫学会学術集会
学会区分	国内学会
発表形式	口頭
講演区分	シンポジウム・ワークショップ パネル（公募）
発表者・共同発表者	◎Takao Seki, Yuichi Tsuchiya, Shigeyuki Shichino, Takashi Nishina, Soh Yamazaki, Kouji Matsushima, Hideo Yagita, Ko Okumura, Minoru Tanaka, Hiroyasu Nakano
発表年月日	2024/01/17
国名	日本
開催地 （都市, 国名）	幕張メッセ
開催期間	2024/01/17～2024/01/19
概要	Liver fibrosis results from chronic liver injury triggered by factors such as viral infection, excess alcohol intake, and lipid accumulation. However, the mechanisms underlying liver fibrosis are not fully understood. Here, we demonstrate that the expression of fibroblast growth factor 18 (Fgf18) is elevated in mouse livers following the induction of chronic liver fibrosis models. Deletion and overexpression of Fgf18 in hepatocytes attenuated and promoted liver fibrosis, respectively. Single-cell RNA sequencing revealed that overexpression of Fgf18 in hepatocytes results in an increase in the number of Lrat+ hepatic stellate cells (HSCs), thereby inducing fibrosis. Mechanistically, FGF18 stimulates the proliferation of HSCs by inducing the expression of Ccnd1. Moreover, the expression of FGF18 is correlated with the expression of profibrotic genes, such as COL1A1 and ACTA2, in human liver biopsy samples. Thus, FGF18 promotes liver fibrosis and could serve as a therapeutic target to treat liver fibrosis.