シラガ　ノブユキ   Shiraga Nobuyuki   白神　伸之    所属   東邦大学  医学部 医学科    職種   特任教授
言語種別	英語
発表タイトル	Impact and Usefulness of Xenon Ventilation CT Using Dual Energy Technique in Patients with Pulmonary Emphysema:A Feasible Study
会議名	98th Radiological Society of North America
学会区分	国際学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Kobayashi M, Shiraga N, Suzuki K, Okada Y, Sugino K, Homma S.
発表年月日	2012/12/03
開催地 （都市, 国名）	Chicago, USA
概要	Purpose: To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in patients with pulmonary emphysema. Methods and Materials: Institutional review board approval and written informed consent were obtained. Ten patients (mean age: 75 years, range: 56-87 years) with pulmonary emphysema and seven healthy volunteers (mean age: 30 years, range: 25-38 years) underwent xenon ventilation CT with single inhalation of 35% xenon gas, using dual-source and dual-energy technique. Scanned data of 2mm thickness were analyzed with three-material-decomposition method on off-lined computer of CT console and xenon-enhanced images were obtained. After three-dimensional (3D) reconstruction of xenon-enhanced images, mean xenon enhancement values of whole lung were measured and correlated with pulmonary function test results. Results: We could successfully obtain xenon enhanced images calculated by using three-material-decomposition method for all subjects. In all healthy volunteers, xenon was distributed homogeneously. In contrast, in all of the seven emphysema cases, total decrease and inhomogeneous distribution of xenon enhancement of lung fields were well demonstrated with 3D images. Mean xenon enhancement values in patients with pulmonary emphysema were significantly lower than those in healthy volunteers (20.8±7.2 vs 32.3±3.5 HU; p<0.01). In relationship with pulmonary function tests, mean xenon enhancement values showed significant positive correlations with forced expiratory volume [FEV1, (r=0.87, p<0.01)], FEV1/forced vital capacity[FVC, (r=0.70, p<0.05)], and　peak flow rate [PEF, (r=0.86, p<0.01)]in pulmonary emphysema cases. Conclusion: For pulmonary emphysema, xenon ventilation CT using dual-source and dual-energy technique has clinical impact in recognizing the distribution and grade of emphysema, and also has the potential to predict respiratory function precisely.