マギ　シゲユキ   Magi Shigeyuki   間木　重行    所属   東邦大学  医学部 医学科    職種   助教
言語種別	英語
種別	部分執筆
表題	Mathematical modeling of cancer signaling addressing tumor heterogeneity
書名	Methods of Mathematical Oncology
ISBNコード	9789811648663
編者名	Takashi SuzukiClair PoignardMark ChaplainVito Quaranta
版・巻・頁	370,pp.141-152
出版社	Springer, Singapore
出版地 （都市, 国名）	Singapore
著者・共著者	Shigeyuki Magi†
発行年月	2021/08/22
概要	One of the obstacles for cancer therapies is the heterogeneity of cancers. Heterogeneity in signal transduction within the same cell population contributes to drug resistance and stemness, and the diversity of cancer subtypes contributes to different therapeutic efficacy between individuals. However, the whole mechanisms associated with heterogeneity in signal transduction are poorly understood. In this review, I introduce several mathematical modeling studies to deal with cell-to-cell variability and diversity of cancer subtypes. Mathematical modeling studies to analyze the heterogeneity of signal transduction should provide new insights that will promote the next generation of cancer therapies, such as overcoming drug resistance and personalized medicine.
AmazonURL	https://www.amazon.co.jp/Methods-Mathematical-Oncology-Mathematics-Proceedings/dp/9811648654
Amazon画像URL	https://images-na.ssl-images-amazon.com/images/I/41nVqiY8ypL._SX313_BO1,204,203,200_.jpg