フルタ トシアキ   Furuta Toshiaki
  古田 寿昭
   所属   東邦大学  理学部 生物分子科学科
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Isostere-Based Design of 8-Azacoumarin-type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls
掲載誌名 正式名:Organic Letters
巻・号・頁 16(4),pp.1184-1187
著者・共著者 Narumi T, Takano H, Ohashi N, Suzuki A, Furuta T†, Tamamura H*
発行年月 2014/02
概要 Described is the development of 8-azacoumarin-4-ylmethyl groups as aqueous photolabile protecting groups. A key feature of the strategy is the isosteric replacement of the C7–C8 enol double bond of the Bhc derivative with an amide bond, resulting in conversion of the chromophore from coumarin to 8-azacoumarin. This strategy makes dramatically enhanced water solubility and facile photocleavage possible.