フルタ　トシアキ   Furuta Toshiaki   古田　寿昭    所属   東邦大学  理学部 生物分子科学科    職種   教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Designing caged compounds for spatiotemporal control of cellular chemistry
掲載誌名	正式名：Journal of Synthetic Organic Chemistry, Japan
掲載区分	国内
巻・号・頁	69(11),pp.1164-1169
著者・共著者	T. Furuta
担当区分	筆頭著者,責任著者
発行年月	2012/11
概要	Photoirradiation of an appropriately designed caged compound enables the control and manipulation of biological processes in living cells with high spatial and temporal resolution. Brominated (coumarin-4-yl)methyl groups were designed to have favorable photochemical and physical properties as photoremovable protecting groups of caged compounds. Caged compounds of various types of biologically related molecules including neurotransmitters, second messengers, inhibitors of some proteins and mRNAs have been synthesized. A membrane-permeable caged cGMP, Bhc-cGMP/Ac, controlled a cGMP-dependent signaling pathway in a freely swimming sperm cell. Spot illumination of Bhcmoc-diC8 produced localized accumulation of diacylglycerol in a single T-cell.