ユアサ レナ
Yuasa Rena
湯浅 玲奈 所属 東邦大学 看護学部 看護学科 職種 教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Iodide induces transforming factor beta 1 (TGFβ1) in RNA in sheep thyroid cells |
掲載誌名 | 正式名:Thyroid 略 称:Thyroid |
掲載区分 | 国外 |
出版社 | Mary Ann Libert., Inc. publishers |
巻・号・頁 | 2(2),pp.141-145 |
総ページ数 | 5 |
著者・共著者 | Yuasa R, Eggo M.C., Meinkoth M., Dillmann WH, Burrow GN. |
担当区分 | 筆頭著者,責任著者 |
発行年月 | 1992/02 |
概要 | We examined TGF-beta mRNA levels in primary sheep thyroid cell cultures to determine whether the inhibitory effects of iodide on thyroid cells could be explained by an induction of TGF-beta mRNA and if this induction was mediated by iodine organification. Thyroid cells were incubated with TSH and five additives (insulin, somatostatin, growth hormone, transferrin, and glycyl-L-histidyl-L-lysin) for 2-3 weeks and then were exposed to sodium iodide (NaI) or 1-methylimidazole-2-thiol (methimazole, MMI), or both for 72 h. Iodide at 10(-6) M and 10(-4) M significantly increased the amount of TGF-beta mRNA as determined by Northern blot analysis with a rat TGF-beta 1 cDNA probe. This increase in TGF-beta 1 mRNA was abolished by the addition of methimazole, an inhibitor of organification. These data indicate that the effects of iodide on thyroid growth and function may be mediated by a process that involves organification of iodide and increases in TGF-beta 1 mRNA levels. |