イシダ　マサヒロ   Ishida Masahiro   石田　政弘    所属   東邦大学  医学部 医学科（大橋病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	RETINAL PIGMENT EPITHELIUM UNDULATIONS IN ACUTE STAGE OF VOGT-KOYANAGI-HARADA DISEASE Biomarker for Functional Outcomes After High-Dose Steroid Therapy
掲載誌名	正式名：RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ISSNコード：0275004X
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	36(2),pp.415-421
著者・共著者	Kouhei Hashizume,Yutaka Imamura,Takamitsu Fujiwara,Shigeki Machida,Masahiro Ishida,Daijiro Kurosaka
発行年月	2016/02
概要	Purpose:To determine the clinical significance of retinal pigment epithelium (RPE) undulations in the acute stage of Vogt-Koyanagi-Harada disease.Methods:Retinal pigment epithelium undulations were detected and classified into 3 grades: Grade 1, slight; Grade 2, moderate; and Grade 3, severe undulations, in the enhanced depth imaging optical coherence tomographic images. The relationship between the clinical characteristics and the presence of RPE undulations was investigated.Results:Among the 61 eyes of 31 patients with Vogt-Koyanagi-Harada disease, 40 eyes had some degree of RPE undulations (Grade 1 = 12, Grade 2 = 15, and Grade 3 = 13). The patients with RPE undulations in both eyes were significantly older at the onset (P = 0.0002). The eyes with RPE undulations were more likely to develop posterior recurrences (P = 0.032) and have worse vision at 12 months (P = 0.043). Multiple regression analysis revealed that RPE undulations were an independent predictor of posterior recurrences (P = 0.009) and poor visual outcomes (P = 0.035).Conclusion:Retinal pigment epithelium undulations detected by enhanced depth imaging optical coherence tomographic are relatively frequent occurrences
DOI	10.1097/IAE.0000000000000728
PMID	26352553