アマノ　ケンジ   Amano   天野　賢治    所属   東邦大学  医学部 医学科（大森病院）    職種   胚培養士
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Central respiratory failure in a mouse model depends on the genetic background of the host.
掲載誌名	正式名：Advances in experimental medicine and biology
掲載区分	国外
巻・号・頁	669,pp.21-4
著者・共著者	Satoru Arata,Kenji Amano,Kazuhiro Yamakawa,Akiko Arata
発行年月	2010
概要	To define the mechanisms of human congenital central respiratory failure, we are examining gene-deficient mice with central respiratory failure. However, the influence of the genetic background of the mice may play an important role in the phenotype of the mice. Therefore, we examined developmental respiratory adaptation in several mouse strains. Neonatal mice from P0 to P3 were examined by whole-body plethysmography and the electro- physiological analysis using brainstem-spinal cord preparations. Our results show that respiratory maturation becomes progressively fixed after birth and that the rate of progression depends on the genetic background of the mice. In particular, the progression of C57BL/6 mice was delayed compared to that of BALB/c mice.
DOI	10.1007/978-1-4419-5692-7_4
PMID	20217313