カタギリ ナオユキ   Katagiri Naoyuki
  片桐 直之
   所属   東邦大学  医学部 医学科(大森病院)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS).
掲載誌名 正式名:psychiatry research: neuroimaging
掲載区分国外
巻・号・頁 30(285),25-30頁
著者・共著者 Katagiri N†, Pantelis C, Nemoto T†, Tsujino N†, Saito J†, Hori M†, Yamaguchi T†, Funatogawa T†, Mizuno M†.
発行年月 2019/03
概要 Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated with changes in the striatum. We investigated if structural changes in the striatum are associated with recovery of sub-threshold psychotic symptoms in subjects with an ARMS who did not develop psychosis (ARMS-N). Sixteen healthy controls and 42 subjects with an ARMS participated in this study. Striatal volumes (caudate, putamen, and nucleus accumbens) were analyzed using MRI. The sub-threshold psychotic symptoms of the subjects with an ARMS were measured using the SOPS. Imaging and symptoms were reevaluated after 52 weeks. Significant right putamen volume reduction was observed at the follow-up in ARMS-N subjects. Improvement in sub-threshold positive symptoms significantly correlated with an increase in volume in the right accumbens at follow up. No relationship was found for negative symptoms. From these findings, the association between improvement in sub-threshold positive symptoms and an increase in the volume of the right accumbens may suggest that changes in the accumbens, which is a major site for dopamine innervation, are associated with symptom recovery. These findings may point to neurobiological resilience that may be associated with lower transition to psychosis.
DOI 10.1016/j.pscychresns.2019.01.008
PMID 30716687