フカサワ　ユリ   Fukasawa Yuri   深澤　由里    所属   東邦大学  医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Histopathological predictor for regional lymph node metastasis in gastric cancer
掲載誌名	正式名：Virchows Archiv : an international journal of pathology 略　 称：Virchows Arch ISSNコード：09456317/14322307
出版社	Springer International
巻・号・頁	454(2),pp.143-151
著者・共著者	Morita H＊†, Ishikawa Y†, Akishima-Fukasawa Y†, Ito K†, Akasaka Y†, Nishimura C†, Igarashi Y†, Miki K†, Ishii T†
発行年月	2009/02
概要	Regional lymph node metastasis in gastric cancer is a definitive indicator of the patient's prognosis. The goal of this study was to identify the predictors for lymph node metastasis among all the possible histopathological parameters, especially by conducting an objective discrimination of the lymphatic and blood vessels. A total of 210 resected primary gastric cancers with or without lymph node metastasis were evaluated based on the conventional histopathological parameters together with immunohistochemistry using antisera-recognizing lymphatic endothelial hyaluronan receptor-1 (LYVE-1), von Willebrand factor, and lymphangiogenesis promoter vascular endothelial growth factor-C (VEGF-C) antibodies. A multivariate regression analyses of the results indicated that only lymphatic invasion was a significant independent predictor of lymph node metastasis at any stage of cancer invasion. VEGF-C expression was partially related to lymph node metastasis in early gastric cancer. The identification of lymphatic invasion by LYVE-1 antibody is therefore useful to predict regional lymph node metastasis in gastric cancer.
DOI	10.1007/s00428-008-0717-3
PMID	19104832