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ヤマガタ トモコ
Yamagata Tomoko
山形 朋子 所属 東邦大学 医学部 医学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | A role for the cortex in sleep–wake regulation |
| 掲載誌名 | 正式名：Nature Neuroscience 略 称：Nat Neurosci ISSNコード：10976256/15461726 |
| 掲載区分 | 国外 |
| 出版社 | NATURE PORTFOLIO |
| 巻・号・頁 | 24,pp.1210-1215 |
| 国際共著 | 国際共著 |
| 著者・共著者 | Lukas B. Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, Martin C. Kahn, Vincent van der Vinne, Laura E. McKillop, Shu K. E. Tam, Stuart N. Peirson, Colin J. Akerman, Anna Hoerder-Suabedissen, Zoltán Molnár & Vladyslav V. Vyazovskiy |
| 担当区分 | 2nd著者 |
| 発行年月 | 2021/08/02 |
| 概要 | Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis. |