カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	MR g-ratio-weighted connectome analysis in patients with multiple sclerosis.
掲載誌名	正式名：Scientific reports ISSNコード：20452322
出版社	NATURE PUBLISHING GROUP
巻・号・頁	9(1),pp.13522-13522
著者・共著者	Koji Kamagata,Andrew Zalesky,Kazumasa Yokoyama,Christina Andica,Akifumi Hagiwara,Keigo Shimoji,Kanako K Kumamaru,Mariko Y Takemura,Yasunobu Hoshino,Kouhei Kamiya,Masaaki Hori,Christos Pantelis,Nobutaka Hattori,Shigeki Aoki
発行年月	2019/09
概要	Multiple sclerosis (MS) is a brain network disconnection syndrome. Although the brain network topology in MS has been evaluated using diffusion MRI tractography, the mechanism underlying disconnection in the disorder remains unclear. In this study, we evaluated the brain network topology in MS using connectomes with connectivity strengths based on the ratio of the inner to outer myelinated axon diameter (i.e., g-ratio), thereby providing enhanced sensitivity to demyelination compared with the conventional measures of connectivity. We mapped g-ratio-based connectomes in 14 patients with MS and compared them with those of 14 age- and sex-matched healthy controls. For comparison, probabilistic tractography was also used to map connectomes based on the number of streamlines (NOS). We found that g-ratio- and NOS-based connectomes comprised significant connectivity reductions in patients with MS, predominantly in the motor, somatosensory, visual, and limbic regions. However, only the g-ratio-based connectome enabled detection of significant increases in nodal strength in patients with MS. Finally, we found that the g-ratio-weighted nodal strength in motor, visual, and limbic regions sign
DOI	10.1038/s41598-019-50025-2
PMID	31534143