カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile analysis.
掲載誌名	正式名：Parkinsonism&related disorders ISSNコード：13538020
出版社	ELSEVIER SCI LTD
巻・号・頁	51,pp.55-60
著者・共著者	Christina Andica,Koji Kamagata,Taku Hatano,Ayami Okuzumi,Asami Saito,Misaki Nakazawa,Ryo Ueda,Yumiko Motoi,Kouhei Kamiya,Michimasa Suzuki,Masaaki Hori,Kanako K Kumamaru,Nobutaka Hattori,Shigeki Aoki
発行年月	2018/06
概要	INTRODUCTION: Parkinson's disease (PD) is marked by the degeneration of dopaminergic neurons in the nigrostriatal pathway (NSP). We aimed to identify the microstructural changes in the NSP of PD patients using neurite orientation dispersion and density imaging (NODDI). METHODS: NSPs of 29 PD patients, who were retrospectively selected from patients previously admitted to our institution, and 29 age- and gender-matched healthy controls were isolated via deterministic tractography. The NODDI indices, intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) were compared between the two groups. The significant results were assessed with a tract-profile analysis. The correlation between indices and disease duration or motor symptom severity was evaluated with the Pearson's correlation test. RESULTS: The contralateral distal Vic (p = 0.00028) of the nigrostriatal pathway was significantly lower in PD patients than in healthy controls. No correlations weredetected between any of the indices and disease duration or motor symptom severity. CONCLUSIONS: NODDI can be used to identify retrograde degeneration of the NSP in PD patients an
DOI	10.1016/j.parkreldis.2018.02.046
PMID	29525556