カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.
掲載誌名	正式名：European radiology ISSNコード：09387994
出版社	SPRINGER
巻・号・頁	26(8),pp.2567-77
著者・共著者	Koji Kamagata,Taku Hatano,Ayami Okuzumi,Yumiko Motoi,Osamu Abe,Keigo Shimoji,Kouhei Kamiya,Michimasa Suzuki,Masaaki Hori,Kanako K Kumamaru,Nobutaka Hattori,Shigeki Aoki
発行年月	2016/08
概要	OBJECTIVES: We used neurite orientation dispersion and density imaging (NODDI) to quantify changes in the substantia nigra pars compacta (SNpc) and striatum in Parkinson disease (PD). METHODS: Diffusion-weighted magnetic resonance images were acquired from 58 PD patients and 36 age- and sex-matched controls. The intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) of the basal ganglia were compared between groups. Multivariate logistic regression analysis determined which diffusion parameters were independent predictors of PD. Receiver operating characteristic (ROC) analysis compared the diagnostic accuracies of the evaluated indices. Pearson coefficient analysis correlated each diffusional parameter with disease severity. RESULTS: Vic in the contralateral SNpc and putamen were significantly lower in PD patients than in healthy controls (P < 0.00058). Vic and OD in the SNpc and putamen showed significant negative correlations (P < 0.05) with disease severity. Multivariate logistic analysis revealed that Vic (P = 0.0000046) and mean diffusivity (P = 0.019) in the contralateral SNpc were the independent predictor
DOI	10.1007/s00330-015-4066-8
PMID	26515546