カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus.
掲載誌名	正式名：NeuroImage. Clinical ISSNコード：22131582
出版社	ELSEVIER SCI LTD
巻・号・頁	14,pp.663-671
著者・共著者	Kouhei Kamiya,Masaaki Hori,Ryusuke Irie,Masakazu Miyajima,Madoka Nakajima,Koji Kamagata,Kouhei Tsuruta,Asami Saito,Misaki Nakazawa,Yuichi Suzuki,Harushi Mori,Akira Kunimatsu,Hajime Arai,Shigeki Aoki,Osamu Abe
発行年月	2017/03/01
概要	The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction of treatment outcome is not established. We investigated changes of the corticospinal tract (CST) in iNPH before and after shunt surgery by using diffusion microstructural imaging, which infers more specific tissue properties than conventional diffusion tensor imaging. Two biophysical models were used: neurite orientation dispersion and density imaging (NODDI) and white matter tract integrity (WMTI). In both methods, the orientational coherence within the CSTs was higher in patients thanin controls, and some normalization occurred after the surgery in patients, indicating axon stretching and recovery. The estimated axon density was lower in patients than in controls but remained unchanged after the surgery, suggesting its potential as a marker for irreversible neuronal damage. In a Monte-Carlo simulation that represented model axons as undulating cylinders, both NODDI and WMTI separated the effects of axon density and undulation. Thus, diffusion MRI may distinguish between reversible and irreversible microstructural changes in iNPH. Our findings constitute a step toward
DOI	10.1016/j.nicl.2017.03.003
PMID	28348958