カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Axon diameter and intra-axonal volume fraction of the corticospinal tract in idiopathic normal pressure hydrocephalus measured by q-space imaging.
掲載誌名	正式名：PloS one ISSNコード：19326203
出版社	PUBLIC LIBRARY SCIENCE
巻・号・頁	9(8),pp.e103842
著者・共著者	Kouhei Kamiya,Masaaki Hori,Masakazu Miyajima,Madoka Nakajima,Yuriko Suzuki,Koji Kamagata,Michimasa Suzuki,Hajime Arai,Kuni Ohtomo,Shigeki Aoki
発行年月	2014/08
概要	PURPOSE: Previous studies suggest that compression and stretching of the corticospinal tract (CST) potentially cause treatable gait disturbance in patients with idiopathic normal pressure hydrocephalus (iNPH). Measurement of axon diameter with diffusion MRI has recently been used to investigate microstructural alterations in neurological diseases. In this study, we investigated alterations in the axon diameter and intra-axonal fraction of the CST in iNPH by q-space imaging (QSI) analysis. METHODS: Nineteen patients with iNPH and 10 age-matched controls were recruited. QSI data were obtained with a 3-T system by using a single-shot echo planar imaging sequence with the diffusion gradient applied parallel to the antero-posterior axis. By using a two-component low-q fit model, the root mean square displacements of intra-axonal space ( =  axon diameter) and intra-axonal volume fraction of the CST were calculated at the levels of the internal capsule and body of the lateral ventricle, respectively. RESULTS: Wilcoxon's rank-sum test revealed a significant increase in CST intra-axonal volume fraction at the paraventricular level in patients (p<0.001), whereas no significant difference
DOI	10.1371/journal.pone.0103842
PMID	25093733