カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Analysis of normal-appearing white matter of multiple sclerosis by tensor-based two-compartment model of water diffusion.
掲載誌名	正式名：European radiology ISSNコード：09387994
出版社	SPRINGER
巻・号・頁	25(6),pp.1701-7
著者・共著者	Yasuhiko Tachibana,Takayuki Obata,Mariko Yoshida,Masaaki Hori,Koji Kamagata,Michimasa Suzuki,Issei Fukunaga,Kouhei Kamiya,Kazumasa Yokoyama,Nobutaka Hattori,Tomio Inoue,Shigeki Aoki
発行年月	2015/06
概要	OBJECTIVES: To compare the significance of the two-compartment model, considering diffusional anisotropy with conventional diffusion analyzing methods regarding the detection of occult changes in normal-appearing white matter (NAWM) of multiple sclerosis (MS). METHODS: Diffusion-weighted images (nine b-values with six directions) were acquired from 12 healthy female volunteers (22-52 years old, median 33 years) and 13 female MS patients (24-48 years old, median 37 years). Diffusion parameters based on the two-compartment model of water diffusion considering diffusional anisotropy was calculated by a proposed method. Other parameters including diffusion tensor imaging and conventional apparent diffusion coefficient (ADC) were also obtained. They were compared statistically between the control and MS groups. RESULTS: Diffusion of the slow diffusion compartment in the radial direction of neuron fibers was elevated in MS patients (0.121 × 10(-3) mm2/s) in comparison to control (0.100 × 10(-3) mm(2)/s), the difference being significant (P = 0.001). The difference between the groups was not significant in other comparisons, including conventional ADC and fractional anisotro
DOI	10.1007/s00330-014-3572-4
PMID	25577520