カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with progressive supranuclear palsy.
掲載誌名	正式名：Journal of neuroradiology = Journal de neuroradiologie ISSNコード：01509861
出版社	MASSON EDITEUR
巻・号・頁	40(2),pp.121-9
著者・共著者	Kouhei Kamiya,Noriko Sato,Miho Ota,Yasuhiro Nakata,Kimiteru Ito,Yukio Kimura,Miho Murata,Harushi Mori,Akira Kunimatsu,Kuni Ohtomo
発行年月	2013/05
概要	OBJECTIVES: The uncinate fasciculus (UF), a major white-matter tract connecting the frontal and temporal lobes, is related to cognitive/behavioral function. Recently, the UF has been suggested to constitute an indirect pathway of the"semantic ventral pathway"in association with the inferior longitudinal fasciculus (ILF). This retrospective study aimed to evaluate damage to the UF and ILF in patients with progressive supranuclear palsy (PSP) using diffusion tensor tract-specific analysis. MATERIAL AND METHODS: Diffusion tensor imaging (DTI) of 16 PSP patients with Richardson's syndrome (PSP-RS) and 21 age-matched volunteers were obtained. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values for the bilateral UF and ILF were calculated by tract-specific analysis. Student's t test was used to evaluate the differences between the patients and controls. Also, voxel-based morphometry (VBM) was performed using 3D T1-weighted images to explore the regional atrophy of gray matter in the patients. RESULTS: In patients with PSP-RS, FA of the left UF was significantly decreased compared with the controls, while significant increases in ADC were found in the UF and ILF b
DOI	10.1016/j.neurad.2012.06.001
PMID	23428241