カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Accelerated myelination along fiber tracts in patients with hemimegalencephaly.
掲載誌名	正式名：Journal of neuroradiology = Journal de neuroradiologie ISSNコード：01509861
出版社	MASSON EDITEUR
巻・号・頁	41(3),pp.202-10
著者・共著者	Kouhei Kamiya,Noriko Sato,Yuko Saito,Yasuhiro Nakata,Kimiteru Ito,Yoko Shigemoto,Miho Ota,Masayuki Sasaki,Kuni Ohtomo
発行年月	2014/07
概要	BACKGROUND AND PURPOSE: In infants with hemimegalencephaly, asymmetrical white-matter intensities suggestive of advanced myelination are observed as well as aberrant midsagittal fibers (AMFs) specific to hemimegalencephaly. Also noted are otherwise unreported abnormally enlarged periventricular fibers (APVFs) running anteroposteriorly along the caudate nucleus. This study investigated the degree of myelination and presence of aberrant fibers in hemimegalencephaly through a retrospective review of MRI scans in relation to histopathological findings. MATERIALS AND METHODS: MRI scans of 24 infants with hemimegalencephaly (13 boys and 11 girls, 1-9 months old) were evaluated, focusing on the presence and signal intensities of AMFs and APVFs. White-matter signal intensities on T1- and T2-weighted imaging of the cerebral hemisphere were also evaluated and compared with the timetable for normal myelination. Surgical specimens were pathologically examined with Klüver-Barrera staining in four patients. RESULTS: AMFs and APVFs were observed in 18 and nine patients, respectively, while 22 patients had accelerated myelination of the megalencephalic hemisphere that tended to extend along fiber
DOI	10.1016/j.neurad.2013.08.005
PMID	24091102