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コモリ コウジ
Komori Kouji
小森 光二 所属 東邦大学 医学部 医学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma |
| 掲載誌名 | 正式名：Journal of Infection and Chemotherapy |
| 掲載区分 | 国外 |
| 出版社 | Elsevier {BV} |
| 巻・号・頁 | 28(8),pp.1212-1215 |
| 著者・共著者 | Ai Kato,Ayumi Yoshifuji,Kohji Komori,Kotaro Aoki,Daisuke Taniyama,Motoaki Komatsu,Kentaro Fujii,Kuniko Yamada,Yoshikazu Ishii,Takahide Kikuchi,Munekazu Ryuzaki |
| 発行年月 | 2022/08 |
| 概要 | A 70-year-old woman, who started on hemodialysis 7 months before for end-stage renal disease due to diabetic nephropathy and was diagnosed with symptomatic multiple myeloma 1 month before, was admitted to our hospital with critical coronavirus disease 2019 and treated with long-term immunosuppressive therapy such as steroids and tocilizumab. During treatment, Bacillus subtilis was detected in the blood cultures. We could not exclude the association of natto (fermented soybeans) with B. subtilis var. natto, which the patient had been eating every day from 8 days after admission. She was prohibited from eating natto and treated with vancomycin. Later, B. subtilis detected in the blood culture was identified as B. subtilis var. natto, which was identical with those contained in the natto that the patient consumed daily using a next-generation sequencer. Gut dysbiosis due to old age, malignant tumor, diabetes mellitus, end-stage renal disease, and intestinal inflammation caused by severe acute respiratory syndrome coronavirus 2 increased intestinal permeability and the risk of bacterial translocation, causing B. subtilis var. natto bacteremia. Therefore, careful consideration might be given to the intake of fermented foods containing live bacteria in patients with severe immunocompromised conditions. |
| DOI | 10.1016/j.jiac.2022.05.006 |
| ORCIDのPut Code | 113472856 |
| PMID | 35618619 |