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コモリ コウジ
Komori Kouji
小森 光二 所属 東邦大学 医学部 医学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report |
| 掲載誌名 | 正式名：BMC Infectious Diseases ISSNコード：1471-2334 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 24(1),pp.374-374 |
| 著者・共著者 | Sho Shimada,Tetsuo Yamaguchi,Satsuki Mikoshiba,Kazuaki Sato,Takahiro Mitsumura,Kohji Komori,Takashi Yamana,Yuki Iijima,Rie Sakakibara,Sho Shibata,Takayuki Honda,Tsuyoshi Shirai,Tsukasa Okamoto,Haruhiko Furusawa,Tomoya Tateishi,Yasunari Miyazaki |
| 発行年月 | 2024/04/04 |
| 概要 | <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The emergence of community-associated methicillin-resistant <jats:italic>Staphylococcus aureus</jats:italic> (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been noted for their severity; however, repeated relapses that require extended antibiotic therapy are rare.</jats:p> </jats:sec><jats:sec> <jats:title>Case presentation</jats:title> <jats:p>We report a case of relapsing bronchopneumonia caused by CA-MRSA in a 56-year-old man. The patient responded to antibiotics, but repeatedly relapsed after stopping treatment. MRSA was consistently isolated from airway specimens during each relapse. Extended oral antibiotic treatment with trimethoprim/sulfamethoxazole (TMP/SMX) for 6 months achieved infection control. Whole-genome sequencing of the isolated strain revealed that the causative agent was sequence type (ST)1/staphylococcal cassette chromosome mec (SCC<jats:italic>mec</jats:italic>) type IVa, a clone that is rapidly increasing in Japan.</jats:p> </jats:sec><jats:sec> <jats:title>Discussion and conclusions</jats:title> <jats:p>This patient had an unusual course of MRSA bronchopneumonia with repeated relapses. Although the choice of antibiotics for long-term use in MRSA respiratory tract infections has not been well established, TMP/SMX was effective and well tolerated for long-term therapy in this case. The clinical course of infections related to the rapid emerging clone, ST1/SCC<jats:italic>mec</jats:italic> type IVa warrants further attention.</jats:p> </jats:sec> |
| DOI | 10.1186/s12879-024-09268-2 |
| ORCIDのPut Code | 159994181 |
| PMID | 38575909 |