コモリ　コウジ   Komori Kouji   小森　光二    所属   東邦大学  医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Daptomycin resistance of Corynebacterium jeikeium due to pgsA gene mutation acquired during daptomycin treatment in a patient with infective endocarditis.
掲載誌名	正式名：International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
掲載区分	国外
巻・号・頁	pp.108112-108112
著者・共著者	Makoto Inada,Kohji Komori,Sohei Harada,Shinya Yamamoto,Koh Okamoto,Ayano Nakazato,Yoshimi Higurashi,Shuhei Matsumoto,Junji Tokushige,Arika Shimura,Takeya Tsutsumi
発行年月	2025/10/10
概要	Daptomycin is an alternative agent for invasive infections caused by Corynebacterium species in patients with intolerance to vancomycin. Although it has recently been recognized that treatment failure with daptomycin due to the emergence of resistant strains during treatment is not uncommon in Corynebacterium striatum infections, it has been unclear whether there is a similar risk in Corynebacterium jeikeium infections. In the presenting case, daptomycin treatment for C. jeikeium endocarditis in a liver transplant recipient with neutropenia failed due to the rapid emergence of the resistant strain. Whole-genome sequencing analysis of blood culture isolates confirmed that a mutation in the pgsA gene, which is also involved in the development of daptomycin resistance in C. striatum, emerged after daptomycin exposure. This case demonstrated that there is a risk of treatment failure due to the emergence of daptomycin-resistant strains even in C. jeikeium infections caused by daptomycin-susceptible strains, particularly in immunocompromised patients and in biofilm infections with high bacterial burden.
DOI	10.1016/j.ijid.2025.108112
PMID	41077331