コモリ　コウジ   Komori Kouji   小森　光二    所属   東邦大学  医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Trends in population structure, antimicrobial susceptibility and resistance determinants of Neisseria gonorrhoeae isolates from surveillance in the Kanto region, Japan, 2017-2023.
掲載誌名	正式名：JAC-antimicrobial resistance
掲載区分	国外
巻・号・頁	8(1),pp.dlag027
著者・共著者	Izumo Kanesaka,Kohji Komori,Masahiro Morita,Kotaro Aoki,Sheeba Santhini Manoharan-Basil,Chris Kenyon,Akiko Kanayama Katsuse,Kazuhiro Tateda,Intetsu Kobayashi,Yoshikazu Ishii
発行年月	2026/02
概要	OBJECTIVES: The spread of antimicrobial-resistant Neisseria gonorrhoeae has limited treatment options. To monitor trends in population structure, antimicrobial susceptibility rates and resistant determinants of gonococcus isolated from patients, we collected longitudinal isolates and performed AST and molecular analyses. METHODS: Of 985 gonococcus isolates obtained from clinical specimens submitted by health care institutions in the Kanto region of Japan between 2017 and 2023, one isolate per patient per year was eligible, and up to 50 isolates per year were randomly selected. A total of 349 isolates were analysed. MICs were determined by the agar dilution method. Multilocus sequence typing and N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) were performed using a high-throughput typing method based on multiplex PCR amplicon sequencing on the MiSeq (Illumina) platform. RESULTS: Over this study period, 29 sequence types (STs) were identified. Only one ceftriaxone non-susceptible strain-harbouring mosaic penA 60.001 and belonging to ST1903-was found in 2017. A ciprofloxacin-susceptible lineage belonging to ST9362, lacking quinolone resistance-determining region mutations, was sporadically predominant in 2018 and 2023. The susceptibility rate to azithromycin remained ≥86% throughout the study period. There was a clear association between lineage and carriage of antimicrobial resistance determinants. CONCLUSIONS: Ceftriaxone remains a reliable first-line treatment option for gonorrhoea. Ongoing surveillance is essential to detect emerging fluoroquinolone-susceptible lineages that may inform future treatment strategies.
DOI	10.1093/jacamr/dlag027
PMID	41783028