カジタニ　タカシ   梶谷　宇    所属   東邦大学  医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers.
掲載誌名	正式名：Cancer science
掲載区分	国外
巻・号・頁	104(12),pp.1647-55
著者・共著者	Masayoshi Iizuka,Takao Susa,Yoshihisa Takahashi,Mimi Tamamori-Adachi,Takashi Kajitani,Hiroko Okinaga,Toshio Fukusato,Tomoki Okazaki
発行年月	2013/12
概要	The estrogen receptor (ER) is a key molecule for growth of breast cancers. It has been a successful target for treatment of breast cancers. Elucidation of the ER expression mechanism is of importance for designing therapeutics for ER-positive breast cancers. However, the detailed mechanism of ER stability is still unclear. Here, we report that histone acetyltransferase Hbo1 promotes destabilization of estrogen receptor α (ERα) in breast cancers through lysine 48-linked ubiquitination. The acetyltransferase activity of Hbo1 is linked to its activity for ERα ubiquitination. Depletion of Hbo1 and anti-estrogen treatment displayed a potent growth suppression of breast cancer cell line. Hbo1 modulated transcription by ERα. Mutually exclusive expression of Hbo1 and ERα was observed in roughly half of the human breast tumors examined in the present study. Modulation of ER stability by Hbo1 in breast cancers may provide a novel therapeutic possibility.
DOI	10.1111/cas.12303
PMID	24125069