オクニシ　カツヒデ   Okunishi Katsuhide   奥西　勝秀    所属   東邦大学  医学部 医学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Upregulation of lung dendritic cell functions in elastase-induced emphysema.
掲載誌名	正式名：International archives of allergy and immunology ISSNコード：1018-2438
掲載区分	国外
出版社	KARGER
巻・号・頁	149 Suppl 1,pp.25-30
著者・共著者	Hiroaki Harada,Mitsuru Imamura,Katsuhide Okunishi,Kazuyuki Nakagome,Taku Matsumoto,Oh Sasaki,Ryoichi Tanaka,Kazuhiko Yamamoto,Makoto Dohi
発行年月	2009
概要	BACKGROUND: Chronic obstructive pulmonary disease (COPD) is now considered a chronic inflammatory disease. Although dendritic cells (DCs) are thought to play a key role in immune responses, studies investigating the role of DCs in COPD are quite limited. METHODS: Porcine pancreas elastase was intratracheally administered to C57BL/6J mice on day 0. On days 2, 7 and 14, emphysema formation was evaluated by pressure-volume relationships and microscopic findings, including measurement of the mean linear intercept. Lung DCs were isolated on day 2, and their ability to stimulate allogeneic T cells and to produce cytokines was examined. RESULTS: Pathologic emphysematous change was observed on day 2 and a significant increase in lung volume was observed on day 14. Lung DC function, such as the induction of T-cell proliferation and IL-10 production, was upregulated. CONCLUSIONS: Upregulation of DC function was observed in elastase-induced emphysema. Further investigation on the contribution to emphysema formation may provide a useful target for future therapy.
DOI	10.1159/000210650
PMID	19494501