オクニシ　カツヒデ   Okunishi Katsuhide   奥西　勝秀    所属   東邦大学  医学部 医学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Perillyl alcohol suppresses antigen-induced immune responses in the lung.
掲載誌名	正式名：Biochemical and biophysical research communications ISSNコード：0006-291X/1090-2104
掲載区分	国外
出版社	ACADEMIC PRESS INC ELSEVIER SCIENCE
巻・号・頁	443(1),pp.266-71
著者・共著者	Mitsuru Imamura,Oh Sasaki,Katsuhide Okunishi,Kazuyuki Nakagome,Hiroaki Harada,Kimito Kawahata,Ryoichi Tanaka,Kazuhiko Yamamoto,Makoto Dohi
発行年月	2014/01/03
概要	Perillyl alcohol (POH) is an isoprenoid which inhibits farnesyl transferase and geranylgeranyl transferase, key enzymes that induce conformational and functional changes in small G proteins to conduct signal production for cell proliferation. Thus, it has been tried for the treatment of cancers. However, although it affects the proliferation of immunocytes, its influence on immune responses has been examined in only a few studies. Notably, its effect on antigen-induced immune responses has not been studied. In this study, we examined whether POH suppresses Ag-induced immune responses with a mouse model of allergic airway inflammation. POH treatment of sensitized mice suppressed proliferation and cytokine production in Ag-stimulated spleen cells or CD4(+) T cells. Further, sensitized mice received aerosolized OVA to induce allergic airway inflammation, and some mice received POH treatment. POH significantly suppressed indicators of allergic airway inflammation such as airway eosinophilia. Cytokine production in thoracic lymph nodes was also significantly suppressed. These results demonstrate that POH suppresses antigen-induced immune responses in the lung. Considering that it exists naturally, POH could be a novel preventive or therapeutic option for immunologic lung disorders such as asthma with minimal side effects.
DOI	10.1016/j.bbrc.2013.11.106
PMID	24309112