スズキ　ノリユキ   Suzuki Noriyuki   鈴木　紀行    所属   東邦大学  薬学部 薬学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry.
掲載誌名	正式名：The Journal of toxicological sciences ISSNコード：18803989/03881350
掲載区分	国外
巻・号・頁	46,pp.193-198
著者・共著者	Makiko Iwase, Yu-ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra.
発行年月	2021/05/01
概要	Laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS) is capable of metal imaging by acquiring local spatial information. However, the preparation of an appropriate standard for quantitative analysis is difficult because the matrices between the standard and the sample should match, and homogeneity of metal concentration in the standard is required. Hence, the aim of this study was to establish a highly quantitative mercury imaging method that utilizes LA-ICP-MS and an appropriate mercury standard consisting of rat tissue. Our standard showed homogeneous mercury concentration and good linearity between concentration and signal intensity, and met the qualifications for quantitative imaging by LA-ICP-MS. Mercury concentration in MeHg-exposed rat kidneys obtained by LA-ICP-MS measurement of the standard (7.84 ± 0.57 µg/g) was comparable to that obtained by cold vapor atomic absorption spectrophotometry (AAS, 7.27 ± 0.46 µg/g). The results indicate that LA-ICP-MS enabled quantitative imaging with the appropriate standard.