スズキ　ノリユキ   Suzuki Noriyuki   鈴木　紀行    所属   東邦大学  薬学部 薬学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Distribution, metabolism, and toxicity of antimony species in wistar rats. A bio-analytical approach.
掲載誌名	正式名：Environmental toxicology and pharmacology ISSNコード：18727077/13826689
掲載区分	国外
巻・号・頁	100,pp.104160-214
国際共著	国際共著
著者・共著者	Yasumitsu Ogra, Nicole Roldán, Marcelo Verdugo, Alexis A. González, Noriyuki Suzuki, Waldo Quiroz.
発行年月	2023/06/04
概要	This work studied the distribution, reactivity, and biological effects of pentavalent or trivalent antimony (Sb(V), Sb(III)) and N-methylglucamine antimonate (NMG-Sb(V)) in Wistar Rats. The expression of fibrosis genes such as α - SMA, PAI-1, and CTGF were determined in Liver, and Kidney tissues. Wistar rats were treated with different concentrations of Sb(V), Sb(III), As(V) and As(III), and MA via intra-peritoneal injections. The results indicated a noteworthy elevation in mRNA levels of plasminogen activator 1 (PAI-1) in the kidneys of rats that were injected. The main accumulation site for Sb(V) was observed to be the liver, from which it is primarily excreted in its reduced form (Sb(III)) through the urine. The generation of Sb(III) in the kidneys has been found to induce damage through the expression of α-SMA and CTGF, and also lead to a higher creatinine clearance compared to As(III).