シライ　トモヒコ   Shirai Tomohiko   白井　智彦    所属   東邦大学  理学部 化学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Asymmetric addition of arylboronic acids to glyoxylate catalyzed by a ruthenium/Me-BIPAM complex
掲載誌名	正式名：Chemical Communications ISSNコード：1359-7345
出版社	ROYAL SOC CHEMISTRY
巻・号・頁	48(22),pp.2803-2805
著者・共著者	Y. Yamamoto,T. Shirai,N. Miyaura
担当区分	2nd著者
発行年月	2012/01
概要	The enantioselective synthesis of a-hydroxy esters by ruthenium-catalyzed 1,2-addition of arylboronic acids to tert-butyl glyoxylate is described. The use of RuCl2(PPh3)(3) with (R, R)-Me-BIPAM gave optically active mandelic acids of up to 99% ee. Addition of a fluoride salt such as potassium fluoride (KF) or caesium fluoride (CsF) was effective for achieving high enantioselectivities.
DOI	10.1039/c2cc17339e