シライ　トモヒコ   Shirai Tomohiko   白井　智彦    所属   東邦大学  理学部 化学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cationic Iridium/S-Me-BIPAM-Catalyzed Direct Asymmetric Intermolecular Hydroarylation of Bicycloalkenes
掲載誌名	正式名：Angewandte Chemie International Edition ISSNコード：1433-7851/1521-3773
出版社	WILEY-V C H VERLAG GMBH
巻・号・頁	54(34),pp.9894-9897
著者・共著者	T. Shirai,Y. Yamamoto
担当区分	筆頭著者
発行年月	2015/08
概要	Highly enantioselective cationic iridium-catalyzed hydroarylation of bicycloalkenes, by carbonyl-directed C-H bond cleavage, was accomplished using a newly synthesized sulfur-linked bis(phosphoramidite) ligand (S-Me-BIPAM). The reaction provides alkylated acetophenone or benzamide derivatives in moderate to excellent yields and good to excellent enantioselectivities. Notably, the hydroarylation reaction of 2-norbornene with N,N-dialkylbenzamide proceeds with excellent enantioselectivity (up to 99% ee) and high selectivity for the mono-ortho-alkylation product.
DOI	10.1002/anie.201504563