ニシオ　ジュンコ   Nishio Junko   西尾　純子    所属   東邦大学  医学部 医学科    職種   教授（寄付講座）
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Immunoregulation by the gut microbiota.
掲載誌名	正式名：Cellular and molecular life sciences : CMLS
掲載区分	国外
巻・号・頁	69(21),pp.3635-50
著者・共著者	Junko Nishio,Kenya Honda
担当区分	筆頭著者
発行年月	2012/11
概要	The human intestinal mucosa is constantly exposed to commensal microbiota. Since the gut microbiota is beneficial to the host, hosts have evolved intestine-specific immune systems to co-exist with the microbiota. On the other hand, the intestinal microbiota actively regulates the host's immune system, and recent studies have revealed that specific commensal bacterial species induce the accumulation of specific immune cell populations. For instance, segmented filamentous bacteria and Clostridium species belonging to clusters XIVa and IV induce the accumulation of Th17 cells in the small intestine and Foxp3(+) regulatory T cells in the large intestine, respectively. The immune cells induced by the gut microbiota likely contribute to intestinal homeostasis and influence systemic immunity in the host.
DOI	10.1007/s00018-012-0993-6
PMID	22527722