フルタ　トシアキ   Furuta Toshiaki   古田　寿昭    所属   東邦大学  理学部 生物分子科学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties
掲載誌名	正式名：Organic & Biomolecular Chemistr 略　 称：Org. Biomol. Chem.
掲載区分	国外
巻・号・頁	12,pp.5089-5093
著者・共著者	T. Watanabe, T. Hoshida, J. Sakyo, M. Kishi, S. Tanabe, J. Matsuura, S. Akiyama, M. Nakata, Y. Tanabe, A. Suzuki, S. Watanabe, T. Furuta
担当区分	最終著者,責任著者
発行年月	2014/06/28
概要	A nucleobase-caged peptide nucleic acid (PNA) having a (6-bromo-7-methoxycoumarin)-4-ylmethoxycarbonyl (Bmcmoc) caging group was newly synthesized. The Bmcmoc-caged PNAs were photolyzed to produce parent PNAs with a high photochemical efficiency. Introduction of a single Bmcmoc group was sufficient to suppress polymerase chain reaction (PCR) clamping activity and triplex invasion complex formation. Photo-mediated restoration of the PCR clamping activity was also demonstrated.