ヤマグチ　ヨウコ   Yamaguchi Yoko   山口　陽子    所属   東邦大学  薬学部 薬学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Age-related dysfunction of p53-regulated phagocytic activity in macrophages
掲載誌名	正式名：Biochemical and Biophysical Research Communications ISSNコード：0006-291X/1090-2104
出版社	Elsevier BV
巻・号・頁	529(2),pp.462-466
著者・共著者	Yohko Yamaguchi,Kohei Kaida,Yusuke Suenaga,Akihito Ishigami,Yoshiro Kobayashi,Kisaburo Nagata
担当区分	筆頭著者,責任著者
発行年月	2020/08
概要	Aging promotes polarization of M2-like macrophages to M1-like macrophages and reduces their phagocytic ability. However, the molecular mechanisms underlying these aging-related changes remain poorly understood. Here, we demonstrate that p53 regulates phagocytic activity in macrophages from young mice but not in those from old ones. Macrophages from both old and young mice expressed functional p53 to induce target genes including p21 and Mdm2. In macrophages from young mice, chemically induced p53 decreased phagocytic activity and c-Myc levels, with the latter change reducing M2-related genes. However, in macrophages from old mice, phagocytic activity and c-Myc expression were independent of p53 activity. Furthermore, c-Myc suppression did not affect M2-related genes in old-mouse macrophages. These results demonstrate that dysregulation of p53 function is a molecular mechanism underlying reduced phagocytic activity in aged-mouse macrophages. (C) 2020 Elsevier Inc. All rights reserved.
DOI	10.1016/j.bbrc.2020.05.121