ユアサ　レナ   Yuasa Rena   湯浅　玲奈    所属   東邦大学  看護学部 看護学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Iodide induces transforming factor beta 1 (TGFβ1) in RNA in sheep thyroid cells
掲載誌名	正式名：Thyroid 略　 称：Thyroid
掲載区分	国外
出版社	Mary Ann Libert., Inc. publishers
巻・号・頁	2(2),pp.141-145
総ページ数	5
著者・共著者	Yuasa R, Eggo M.C., Meinkoth M., Dillmann WH, Burrow GN.
担当区分	筆頭著者,責任著者
発行年月	1992/02
概要	We examined TGF-beta mRNA levels in primary sheep thyroid cell cultures to determine whether the inhibitory effects of iodide on thyroid cells could be explained by an induction of TGF-beta mRNA and if this induction was mediated by iodine organification. Thyroid cells were incubated with TSH and five additives (insulin, somatostatin, growth hormone, transferrin, and glycyl-L-histidyl-L-lysin) for 2-3 weeks and then were exposed to sodium iodide (NaI) or 1-methylimidazole-2-thiol (methimazole, MMI), or both for 72 h. Iodide at 10(-6) M and 10(-4) M significantly increased the amount of TGF-beta mRNA as determined by Northern blot analysis with a rat TGF-beta 1 cDNA probe. This increase in TGF-beta 1 mRNA was abolished by the addition of methimazole, an inhibitor of organification. These data indicate that the effects of iodide on thyroid growth and function may be mediated by a process that involves organification of iodide and increases in TGF-beta 1 mRNA levels.