カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Temporal Lobe Epilepsy with Unilateral Amygdala Enlargement: Morphometric MR Analysis with Clinical and Pathological Study
掲載誌名	正式名：JOURNAL OF NEUROIMAGING ISSNコード：10512284
出版社	WILEY
巻・号・頁	25(2),pp.175-183
著者・共著者	Yukio Kimura,Noriko Sato,Yuko Saito,Kimiteru Ito,Kouhei Kamiya,Yasuhiro Nakata,Masako Watanabe,Norihide Maikusa,Hiroshi Matsuda,Hideharu Sugimoto
発行年月	2015/03
概要	BACKGROUND AND PURPOSEAmygdala enlargement (AE) has been reported as an epileptogenic focus in subtypes of temporal lobe epilepsy (TLE). The purpose of this study was to investigate the clinical, morphological, and pathological characteristics of AE.METHODSWe retrospectively reviewed the clinical data and imaging findings of 23 TLE patients with ipsilateral AE. We performed morphological MR analyses using FreeSurfer and voxel-based morphometry (VBM) in 14 of the 23 patients and in 20 controls whose images were obtained by a 3.0-Tesla MRI. A pathological study was also performedin 2 patients who underwent operations.RESULTSAll patients became seizure free or shSowed dramatic improvement by medical therapy except for two. They received operations and their pathology revealed that both patients had cortical dysplasia in from the amygdala to the ipsilateral temporal pole. The FreeSurfer analysis showed a significant difference in the amygdala volumes between the affected and nonaffected sides. VBM revealed significant increases of gray matter volumes of the temporal pole on the side of AE in seven of the 14 patients with AE (50%).CONCLUSIONSCortical dysplasia may be one of the patholo
DOI	10.1111/jon.12106