カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Usefulness of SWI for the Detection of Iron in the Motor Cortex in Amyotrophic Lateral Sclerosis
掲載誌名	正式名：JOURNAL OF NEUROIMAGING ISSNコード：10512284
出版社	WILEY
巻・号・頁	25(3),pp.443-451
著者・共著者	Yuko Adachi,Noriko Sato,Yuko Saito,Yukio Kimura,Yasuhiro Nakata,Kimiteru Ito,Kouhei Kamiya,Hiroshi Matsuda,Tadashi Tsukamoto,Masahumi Ogawa
発行年月	2015/05
概要	PURPOSEThe purpose of the present retrospective study was to evaluate the sensitivity of susceptibility-weighted imaging (SWI) compared to conventional spin-echo T2-weighted and T2*-weighted images in detecting iron deposition in the motor cortex of amyotrophic lateral sclerosis (ALS) patients in comparison with age-matched normal controls. We also investigated the etiology of the low signal referring to the pathology of one autopsy case.METHODSThis retrospective magnetic resonance (MR) study included 23 ALS patients and 28 age-matched normal controls. The signal intensity of the motor cortex was scored by SWI, conventional T2-weighted images and T2*-weighted images. A postmortem study of one patient was also performed.RESULTSOn SWI, there was a significant difference between the precentral cortical signal intensity scores in the ALSpatients and the controls (P<.0001). The total scores of signal intensities of the precentral cortex were positively correlated with age in the normal controls (r = .494), but no correlation was observed in the ALS patients. The postmortem study showed intensely stained microglias and macrophages after antiferritin antibody staining in the precentral
DOI	10.1111/jon.12127