カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Time-dependent Diffusion in Transient Splenial Lesion: Comparison between Oscillating-Gradient Spin-echo Measurements and Monte-Carlo Simulation.
掲載誌名	正式名：Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
巻・号・頁	pp.1
著者・共著者	Tomoko Maekawa,Kouhei Kamiya,Katsutoshi Murata,Thorsten Feiweier,Masaaki Hori,Shigeki Aoki
担当区分	2nd著者
発行年月	2020/07
概要	The microstructural underpinnings of reduced diffusivity in transient splenial lesion remain unclear. Here, we report findings from oscillating gradient spin-echo (OGSE) diffusion imaging in a case of transient splenial lesion. Compared with normal-appearing white matter, the splenial lesion exhibited greater differences between diffusion time t = 6.5 and 35.2 ms, indicating microstructural changes occurring within the corresponding length scale. We also conducted 2D Monte-Carlo simulation. The results suggested that emergence of small and non-exchanging compartment, as often imagined in intramyelinic edema, does not fit well with the in vivo observation. Simulations with axonal swelling and microglial infiltration yielded results closer to the in vivo observations. The present report exemplifies the importance of controlling t for more specific radiological image interpretations.
DOI	10.2463/mrms.bc.2020-0046
PMID	32611990