カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for the Spinal Cord in Cervical Spondylotic Myelopathy.
掲載誌名	正式名：Scientific reports ISSNコード：20452322
出版社	NATURE PUBLISHING GROUP
巻・号・頁	8(1),pp.5213-5213
著者・共著者	Masaaki Hori,Akifumi Hagiwara,Issei Fukunaga,Ryo Ueda,Kouhei Kamiya,Yuichi Suzuki,Wei Liu,Katsutoshi Murata,Tomohiro Takamura,Nozomi Hamasaki,Ryusuke Irie,Koji Kamagata,Kanako Kunishima Kumamaru,Michimasa Suzuki,Shigeki Aoki
発行年月	2018/03
概要	Mapping of MR fiber g-ratio, which is the ratio of the diameter of the axon to the diameter of the neuronal fiber, is introduced in this article. We investigated the MR fiber g-ratio, the axon volume fraction (AVF) and the myelin volume fraction (MVF) to evaluate microstructural changes in the spinal cord in patients with cervical spondylotic myelopathy (CSM) in vivo, using atlas-based analysis. We used diffusion MRI data acquired with a new simultaneous multi-slice accelerated readout-segmented echo planar imaging sequence for diffusion analysis for AVF calculation and magnetization transfer saturation imaging for MVF calculation. The AVFs of fasciculus gracilis in the affected side spinal cord, fasciculus cuneatus and lateral corticospinal tracts (LSCT) in the affected and unaffected side spinal cord were significantly lower (P = 0.019, 0.001, 0019, 0.000, and 0.002, respectively) than those of normal controls. No difference was found in the MVFs. The fiber g-ratio of LSCT was significantly lower (P = 0.040) in the affected side spinal cords than in the normal controls. The pathological microstructural changes in the spinal cord in patients with CSM, presumably partial ax
DOI	10.1038/s41598-018-23527-8
PMID	29581458