カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder.
掲載誌名	正式名：NMR in biomedicine ISSNコード：09523480
出版社	WILEY
巻・号・頁	31(7),pp.e3938
著者・共著者	Kouhei Kamiya,Naohiro Okada,Kingo Sawada,Yusuke Watanabe,Ryusuke Irie,Shouhei Hanaoka,Yuichi Suzuki,Shinsuke Koike,Harushi Mori,Akira Kunimatsu,Masaaki Hori,Shigeki Aoki,Kiyoto Kasai,Osamu Abe
発行年月	2018/07
概要	Major depressive disorder (MDD) is a globally prevalent psychiatric disorder that results from disruption of multiple neural circuits involved in emotional regulation. Although previous studies using diffusion tensor imaging (DTI) found smaller values of fractional anisotropy (FA) in the white matter, predominantly in the frontal lobe, of patients with MDD, studies using diffusion kurtosis imaging (DKI) are scarce. Here, we used DKI whole-brain analysis with tract-based spatial statistics (TBSS) to investigate the brain microstructural abnormalities in MDD. Twenty-six patients with MDD and 42 age- and sex-matched control subjects were enrolled. To investigate the microstructural pathology underlying the observations in DKI, a compartment model analysis was conducted focusing on the corpus callosum. In TBSS, the patients with MDD showed significantly smaller values of FA in the genu and frontal portion of the body of the corpus callosum. The patients also had smaller values of mean kurtosis (MK) and radial kurtosis (RK), but MK and RK abnormalities were distributed more widely compared with FA, predominantly in the frontal lobe but also in the parietal, occipital, and temporal lobes
DOI	10.1002/nbm.3938
PMID	29846988